Understanding of the Harmful effects of drug abuse/misuse 1


  • *Addiction vs. Dependence* When people talk about addiction, they are usually referring to the harmful behavior associated with substance abuse. Dependence refers to the physical symptoms of withdrawal and tolerance
  • *The difference between addiction and dependence* can be difficult to understand. Some organizations have different definitions, use the words interchangeably or even abandon both terms altogether. (“Substance use disorder” is a preferred term in the scientific community.) Because of this lack of consistency, some ground rules can help differentiate between the two terms. When people use the term *“dependence,”* they are usually referring to a physical dependence on a substance. *Dependence* is characterized by the symptoms of tolerance and withdrawal. While it is possible to have a physical dependence without being addicted, addiction is usually right around the corner. *Addiction* is marked by a change in behavior caused by the biochemical changes in the brain after continued substance abuse. Substance use becomes the main priority of the addict, regardless of the harm they may cause to themselves or others. An addiction causes people to act irrationally when they don’t have the substance they are addicted to in their system. “ *Addiction* encompasses both a mental and physical reliance on a given substance. ” 
  •  *Mental Dependence vs. Physical Dependence* Mental dependence is when use of a substance is a conditioned response to an event or feeling. These are known as “triggers.” “ Triggers can be emotional responses to events, certain people, places or anything a person associates with using a substance. ” Something as simple as driving can trigger a desire to use. These triggers set off biochemical changes in a person’s brain that strongly influence addictive behavior. When the symptoms of mental and physical dependence are apparent, an addiction is usually present. However, the main characteristic that distinguishes addiction from dependence is the combination of mental and physical dependence with uncontrollable behavior in obtaining and using a substance. So, why do some organizations scrap the word “addiction” from their vocabulary? The DSM believes the term carries too much negative connotation and is ambiguous. The World Health Organization also wanted to replace the medical designation of “addiction” with the word “dependence” back in 1964 (which probably contributed to the confusion). 
  • *Tolerance* is a person's diminished response to a drug, which occurs when the drug is used repeatedly and the body adapts to the continued presence of the drug. Resistance refers to the ability of microorganisms or cancer cells to withstand the effects of a drug usually effective against them. 
  •  *threshold* dose the minimum dose of ionizing radiation, a chemical, or a drug that will produce a detectable degree of any given effect.

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